Cold-Sensitive Corneal Afferents Respond to a Variety of Ocular Stimuli Central to Tear Production: Implications for Dry Eye Disease

摘要

Innocuous “cold” cornea afferents were excited by the ocular stimuli (drying, cooling, evaporation, and hyperosmolar stress of the cornea) that normally produce tears. Dysfunction of these corneal afferents may be responsible for some forms of dry eye.